Their graduates racked up more than twice as many top-flight minutes played as the next best academy.
Players who finished their youth careers in the United academy were on the field for a total of 44,055 minutes in the study. Tottenham were second, with a total of 21,668.
The Red Devils' reputation for developing home-grown talent extends back to the "Busby Babes" of the 1950s and continued through the "Class of '92" group which played a part in the United side that dominated domestic football in the 1990s and won the treble in 1999.
The study, using publicly available data, shows that the United academy is still the number one producer of top-flight talent in England.
In their own line-up, France midfielder Paul Pogba -- who re-joined United last summer in an £89 million deal -- racked up 2,609 minutes while England internationals Marcus Rashford and Jesse Lingard played 1,702 and 1,367 minutes respectively.
Other non-United players to make significant contributions to the Red Devils academy total included Burnley duo Michael Keane and Tom Heaton, who each played 3,150 minutes. England defender Keane has since joined Everton.
Bournemouth striker Joshua King played 2,721 minutes, while Leicester pair Danny Simpson (2,990) and Danny Drinkwater (2,466) were also key to the high total for United.
Stoke defender Ryan Shawcross played 3,150 minutes while relegated Sunderland used five United academy products during the season -- John O'Shea, Donald Love, Paddy McNair, Darron Gibson and Adnan Januzaj. West Brom duo Jonny Evans (2,638) and Darren Fletcher (3,235) also came through the United system.